4α-(ethoxymethoxy)-4β-({[(4-methylphenyl)sulfonyl]oxy}methyl)-5α-cholestan-3β-ol

Base Information

Chemical Name:4α-(ethoxymethoxy)-4β-({[(4-methylphenyl)sulfonyl]oxy}methyl)-5α-cholestan-3β-ol
CAS No.:656227-67-7
Molecular Formula:C₃₈H₆₂O₆S
Molecular Weight:646.973
Hs Code.:

Synonyms:4α-(ethoxymethoxy)-4β-({[(4-methylphenyl)sulfonyl]oxy}methyl)-5α-cholestan-3β-ol

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Chemical Property of 4α-(ethoxymethoxy)-4β-({[(4-methylphenyl)sulfonyl]oxy}methyl)-5α-cholestan-3β-ol

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Technology Process of 4α-(ethoxymethoxy)-4β-({[(4-methylphenyl)sulfonyl]oxy}methyl)-5α-cholestan-3β-ol

There total 5 articles about 4α-(ethoxymethoxy)-4β-({[(4-methylphenyl)sulfonyl]oxy}methyl)-5α-cholestan-3β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 98-59-9
p-toluenesulfonyl chloride

: 656227-66-6
4α-(ethoxymethoxy)-4β-(hydroxymethyl)-5α-cholestan-3β-ol

: 656227-67-7
4α-(ethoxymethoxy)-4β-({[(4-methylphenyl)sulfonyl]oxy}methyl)-5α-cholestan-3β-ol

Guidance literature:: With pyridine; dmap; at 20 ℃; for 17h;
DOI:10.1002/hlca.200390306

Reference yield:

: Acetic acid (3S,5R,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-4-methylene-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

: 656227-67-7
4α-(ethoxymethoxy)-4β-({[(4-methylphenyl)sulfonyl]oxy}methyl)-5α-cholestan-3β-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / OsO₄; pyridine / diethyl ether; benzene / 6 h / 20 °C

2: 99 percent / 4-(dimethylamino)pyridine; pyridine / CH₂Cl₂ / 0.75 h / 20 °C

3: 95 percent / i-Pr₂NEt

4: 98 percent / LiAlH₄ / diethyl ether / 0.25 h / 20 °C

5: 89 percent / DMAP; pyridine / 17 h / 20 °C

With pyridine; dmap; osmium(VIII) oxide; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; benzene;
DOI:10.1002/hlca.200390306

Reference yield:

: 656227-63-3
3β-acetoxy-4β-(hydroxymethyl)-5α-cholestan-4α-ol

: 656227-67-7
4α-(ethoxymethoxy)-4β-({[(4-methylphenyl)sulfonyl]oxy}methyl)-5α-cholestan-3β-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 4-(dimethylamino)pyridine; pyridine / CH₂Cl₂ / 0.75 h / 20 °C

2: 95 percent / i-Pr₂NEt

3: 98 percent / LiAlH₄ / diethyl ether / 0.25 h / 20 °C

4: 89 percent / DMAP; pyridine / 17 h / 20 °C

With pyridine; dmap; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1002/hlca.200390306