(1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol

Base Information

Chemical Name:(1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol
CAS No.:133299-34-0
Molecular Formula:C₂₁H₂₇N₅O₄
Molecular Weight:413.476
Hs Code.:

Synonyms:(1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol

Suppliers and Price of (1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol

There total 6 articles about (1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 133299-33-9
(1'R,3'S,4'R)-9-<4-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl>-6-(2-methoxyethoxy)-9H-purin-2-amine

: 133299-34-0
(1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol

Guidance literature:: With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1039/P19910002479

Reference yield:

: 105797-60-2
2-amino-6-(2-methoxyethoxy)purine

: 133299-34-0
(1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithium hydride / 1) DMF, 120 deg C, 1 h, 2) DMF, 145 deg C, 3.5 h

2: 90 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.75 h

3: 79 percent / Bu₃SnH, azoisobutyronitrile / toluene / 1 h / 100 °C

4: 66 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, water / CH₂Cl₂

With dmap; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; lithium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; toluene;
DOI:10.1039/P19910002479

Reference yield:

: 117641-39-1
(2R,3S)-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexan-3-ol

: 133299-34-0
(1S,2R,4R)-4-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethylcyclopentanol

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH, 2) tetrabutylammonium iodide / 1) THF, r.t., 1 h, 2) DMF, reflux, 1.5 h

2: 1) lithium hydride / 1) DMF, 120 deg C, 1 h, 2) DMF, 145 deg C, 3.5 h

3: 90 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.75 h

4: 79 percent / Bu₃SnH, azoisobutyronitrile / toluene / 1 h / 100 °C

5: 66 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, water / CH₂Cl₂

With dmap; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; lithium hydride; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; toluene;
DOI:10.1039/P19910002479