Technology Process of Nothoapiole
There total 4 articles about Nothoapiole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-allyl-4,7-dimethoxy-1,3-benzodioxol-5-ol;
With
sodium hydroxide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.333333h;
dimethyl sulfate;
In
N,N-dimethyl-formamide;
for 2h;
DOI:10.1021/acs.jnatprod.8b00878
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: formic acid; dihydrogen peroxide / 20 °C
2.1: sodium hydroxide / N,N-dimethyl-formamide / 0.33 h / 20 °C
2.2: 1 h
3.1: N,N-dimethyl-aniline / 2.5 h / Reflux
4.1: sodium hydroxide / N,N-dimethyl-formamide / 0.33 h / 20 °C
4.2: 2 h
With
formic acid; dihydrogen peroxide; N,N-dimethyl-aniline; sodium hydroxide;
In
N,N-dimethyl-formamide;
3.1: |Claisen Rearrangement;
DOI:10.1021/acs.jnatprod.8b00878
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / N,N-dimethyl-formamide / 0.33 h / 20 °C
1.2: 1 h
2.1: N,N-dimethyl-aniline / 2.5 h / Reflux
3.1: sodium hydroxide / N,N-dimethyl-formamide / 0.33 h / 20 °C
3.2: 2 h
With
N,N-dimethyl-aniline; sodium hydroxide;
In
N,N-dimethyl-formamide;
2.1: |Claisen Rearrangement;
DOI:10.1021/acs.jnatprod.8b00878
