Synonyms:Cinnamate;Cinnamates
99% *data from raw suppliers
There total 1 articles about Cinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield:
Reference yield: 95.0%
Reference yield: 56.0%
The research investigates the design, synthesis, and evaluation of novel cinnamate, thiocinnamate, and thionocinnamate analogs derived from natural products for their ability to inhibit the expression of cell adhesion molecules (CAMs) on human endothelial cells. The study aims to identify potent inhibitors of TNF-α-induced ICAM-1, VCAM-1, and E-selectin expression, which are critical in inflammatory responses. The key chemicals used include various cinnamates, thiocinnamates, and thionocinnamates, with ethyl 3,4,5-trimethoxythionocinnamate (ETMTC) emerging as the most potent inhibitor. The research concludes that these compounds, particularly ETMTC, significantly inhibit the expression of CAMs and neutrophil adhesion to endothelial cells, suggesting their potential as anti-inflammatory agents. The findings highlight the importance of the alkyl chain length, the number of methoxy groups, and the presence of sulfur in the structure for enhancing inhibitory activity.
The research aimed to develop an efficient method for the synthesis of vicinal bromoazides directly from olefins using N,N-dibromo-p-toluenesulfonamide (TsNBr2) as the bromine source and trimethylsilyl azide (TMSN3) as the azide source, without the need for any catalyst. The study concluded that this method is extremely rapid and efficient, applicable to various olefins such as cinnamates, chalcone, styrenes, and acrylates, yielding the corresponding 1,2-bromoazides in excellent yields. The reaction is particularly effective for α,β-unsaturated carbonyl compounds, which are known to be challenging for such transformations. However, the reaction was found to be less effective for aliphatic alkenes like cyclohexene and 1-octene. The procedure is performed at room temperature in acetonitrile as the solvent, and the reaction is instantaneous, highlighting its ease of performance.
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