Chemical Property of Eurycomanone
Chemical Property:
- Vapor Pressure:8.66E-21mmHg at 25°C
- Melting Point:273-285℃ (methanol ethyl ether )
- Boiling Point:669.5°C at 760 mmHg
- PKA:11.29±0.70(Predicted)
- Flash Point:239.9°C
- PSA：172.21000
- Density:1.63g/cm3
- LogP:-1.95660
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Pyridine (Slightly, Son
- XLogP3:-2.8
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:0
- Exact Mass:408.14203234
- Heavy Atom Count:29
- Complexity:896
- Purity/Quality:
-
≥98% *data from raw suppliers
Eurycomanone *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=O)C(C2(C1CC3C45C2C(C(C(=C)C4(C(C(=O)O3)O)O)O)(OC5)O)C)O
- Isomeric SMILES:CC1=CC(=O)[C@H]([C@]2([C@H]1C[C@@H]3[C@]45[C@@H]2[C@]([C@@H](C(=C)[C@@]4([C@H](C(=O)O3)O)O)O)(OC5)O)C)O
-
Uses
Eurycomanone is known as a cytotoxic compound found in Eurycoma Longifolia Jack. Previous studies had noted its cytotoxic effects against various cancer cell lines. More recent research demonstrated the ability of Eurycomanone to suppress the expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Eurycomanone was shown to also exerts the ability to induce apoptosis through the up-regulation of p53 in human cervical carcinoma cells.
