C₁₉H₁₇ClN₄O

Base Information

• Chemical Name: C₁₉H₁₇ClN₄O
• CAS No.: 1547160-99-5
• Molecular Formula: C₁₉H₁₇ClN₄O
• Molecular Weight: 352.823
• Mol file: 1547160-99-5.mol

Synonyms:C₁₉H₁₇ClN₄O

Chemical Property of C₁₉H₁₇ClN₄O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₇ClN₄O

There total 4 articles about C₁₉H₁₇ClN₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C19H15ClN4O3 (1547160-93-9) → C19H17ClN4O (1547160-99-5)

Guidance literature:

With iron; ammonium chloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 1h;

DOI:10.1016/j.bmcl.2013.12.079

Reference yield:

7-fluoro-6-nitro-3H-quinazolin-4-one (162012-69-3) → C19H17ClN4O (1547160-99-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 20 h / 75 °C

2: trichlorophosphate; thionyl chloride / 3 h / 90 °C

3: isopropyl alcohol / 2 h / 50 °C

4: ammonium chloride; iron / N,N-dimethyl-formamide; water / 1 h / 80 °C

With thionyl chloride; iron; sodium hydride; ammonium chloride; trichlorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.12.079

Reference yield:

6-nitro-7-(3-hydroxypropoxy)quinazolin-4-one → C19H17ClN4O (1547160-99-5)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate; thionyl chloride / 3 h / 90 °C

2: isopropyl alcohol / 2 h / 50 °C

3: ammonium chloride; iron / N,N-dimethyl-formamide; water / 1 h / 80 °C

With thionyl chloride; iron; ammonium chloride; trichlorophosphate; In water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.12.079

upstream raw materials:

7-fluoro-6-nitro-3H-quinazolin-4-one

C₁₁H₉Cl₂N₃O₃

C₁₉H₁₅ClN₄O₃

Downstream raw materials:

C₂₈H₃₀N₆O₂

C₂₉H₃₁N₅O₂

C₂₉H₃₁N₅O₂

C₂₈H₂₉N₅O₂