Morphine sulfate

Base Information

• Chemical Name: Morphine sulfate
• CAS No.: 64-31-3
• Deprecated CAS: 66591-53-5,92004-19-8
• Molecular Formula: C34H38N2O6•H2O4S
• Molecular Weight: 383.422
• European Community (EC) Number: 200-582-8,624-082-8
• UNII: X3P646A2J0
• DSSTox Substance ID: DTXSID1048914
• Wikidata: Q27122210
• NCI Thesaurus Code: C669
• RXCUI: 30236
• ChEMBL ID: CHEMBL2103744
• Mol file: 64-31-3.mol

Synonyms:Chloride, Morphine;Contin, MS;Duramorph;Morphia;Morphine;Morphine Chloride;Morphine Sulfate;Morphine Sulfate (2:1), Anhydrous;Morphine Sulfate (2:1), Pentahydrate;MS Contin;Oramorph SR;SDZ 202 250;SDZ 202-250;SDZ 202250;SDZ202 250;SDZ202-250;SDZ202250;Sulfate, Morphine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Morphine sulfate

Chemical Property:

• Vapor Pressure: 7.06E-10mmHg at 25°C
• Melting Point: 250 °C
• Boiling Point: 476.2°C at 760 mmHg
• Flash Point: 241.8°C
• PSA: 135.91000
• LogP: 1.56400
• Storage Temp.: −20°C
• Hydrogen Bond Donor Count: 11
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 0
• Exact Mass: 758.29319007
• Heavy Atom Count: 52
• Complexity: 576

Purity/Quality:

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.O.O.O.O.O.OS(=O)(=O)O
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.O.O.O.O.O.OS(=O)(=O)O
• Recent ClinicalTrials: Morphine Sulfate/Placebo for the Treatment of PulmonAry Fibrosis Cough
• Recent EU Clinical Trials: Gender biases in pain medicine: from omics to healthcare.
• Recent NIPH Clinical Trials: The research to take the oral tablet morphine sulphate for preoperative under general anesthesia: to postoprative pain and sedation
• Uses: Analgesic (narcotic).

Technology Process of Morphine sulfate

There total 2 articles about Morphine sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

MORPHIN (57-27-2) → morphine sulfate (64-31-3,49719-65-5,6211-15-0)

Guidance literature:

With sulfuric acid; In methanol; water; at 55 ℃; for 0.833333h; Solvent; Temperature;

Reference yield:

→ morphine sulfate (64-31-3)

Guidance literature:

Reference yield: 85.0%

morphine sulfate (64-31-3,49719-65-5,6211-15-0) + 3,5-dinitrobenoyl chloride (99-33-2) → C24H21N3O8

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 10 - 20 ℃; for 5h;

upstream raw materials:

MORPHIN

Downstream raw materials:

3,6-diacetylnormethylmorphine

pseudomorphine

4,5α-epoxy-17-((Ξ)-1-methyl-2-phenyl-ethyl)-morphin-7-ene-3,6α-diol

normorphine

Refernces

Hydromorphone metabolites: Isolation and identification from pooled urine samples of a cancer patient

10.1080/00498250110119090

The study focused on the isolation and identification of hydromorphone metabolites from the urine samples of a cancer patient undergoing hydromorphone therapy for pain management. Hydromorphone, a potent semisynthetic opioid, was the primary compound of interest, and its metabolites were analyzed to understand its metabolic fate in the human body. The researchers used various chemicals in the study, including hydromorphone hydrochloride, morphine sulfate, Amberlite XAD-2 resin for urine sample processing, and reagents like palladium on activated carbon for synthesis. They also employed LC/MS/MS (liquid chromatography-tandem mass spectrometry) for the detection and identification of metabolites. The purpose of these chemicals was to synthesize known metabolites for comparison with those found in the patient's urine and to develop a method for isolating and identifying hydromorphone and its metabolites. The study aimed to provide a comprehensive profile of hydromorphone metabolism, which is crucial for understanding its efficacy and safety in clinical use.