4-[3-[3-[Bis(4-isobutylphenyl)methylamino]benzoyl]indol-1-yl]butyric acid

Base Information

Chemical Name:4-[3-[3-[Bis(4-isobutylphenyl)methylamino]benzoyl]indol-1-yl]butyric acid
CAS No.:163136-03-6
Molecular Formula:C40H44 N2 O3
Molecular Weight:600.801
Hs Code.:
Mol file:163136-03-6.mol

Synonyms:FK 143

Suppliers and Price of 4-[3-[3-[Bis(4-isobutylphenyl)methylamino]benzoyl]indol-1-yl]butyric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[3-[3-[Bis(4-isobutylphenyl)methylamino]benzoyl]indol-1-yl]butyric acid

Chemical Property:

Vapor Pressure:1.65E-25mmHg at 25°C
Boiling Point:778.4°C at 760 mmHg
Flash Point:424.6°C
PSA：71.33000
Density:1.11g/cm³
LogP:9.40860

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-[3-[3-[Bis(4-isobutylphenyl)methylamino]benzoyl]indol-1-yl]butyric acid

There total 7 articles about 4-[3-[3-[Bis(4-isobutylphenyl)methylamino]benzoyl]indol-1-yl]butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

: 225942-87-0
ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate

: 163136-03-6
[14C]-FK-143

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; methanol; at 20 ℃; for 14h;
DOI:10.1248/cpb.47.481

Reference yield:

: bis(4-isobutylphenyl)methyl chloride

: 139155-49-0
4-[3-(3-aminobenzoyl)-1H-indol-1-yl]butyric acid

: 163136-03-6
[14C]-FK-143

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; chloroform; benzene;

Reference yield:

: 120-72-9
indole

: 163136-03-6
[14C]-FK-143

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) AlCl₃ / 1.) CH₂Cl₂, 20 deg C, 1 h, 2.) CH₂Cl₂, 25 deg C, 1 h

2: 90 percent / K₂CO₃ / dimethylformamide / 3 h / 40 °C

3: 86.3 percent / H₂ / 10 percent Pd/C / ethanol; dioxane / 0.75 h / 20 °C / 2280 Torr

4: 77.2 percent / iPr₂EtN / CH₂Cl₂ / Ambient temperature

5: 87.5 percent / 1 N aq. NaOH / dioxane; methanol / 14 h / 20 °C

With sodium hydroxide; aluminium trichloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.481