(1R,4R,5R)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one

Base Information

Chemical Name:(1R,4R,5R)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one
CAS No.:342638-17-9
Molecular Formula:C₂₀H₃₁NO₄Si
Molecular Weight:377.556
Hs Code.:

Synonyms:(1R,4R,5R)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one

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Chemical Property of (1R,4R,5R)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one

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Technology Process of (1R,4R,5R)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one

There total 3 articles about (1R,4R,5R)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141565-14-2,77486-09-0,77486-10-3
N-(2-methoxy-2-oxoethylidene)-1-phenylmethanamine N-oxide

: 185317-29-7
(S)-4-((tert-butyldimethylsilyl)oxy)-Z-2-penten-1-ol

: (1S,4S,5S)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one

: 342638-17-9
(1R,4R,5R)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one

Guidance literature:: With 4 A molecular sieve; titanium tetrachloride; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1021/jo001015i

Reference yield:

: 87727-28-4
(S)-2-tert-butyl-dimethyl-silanyloxy propanal

: 342638-17-9
(1R,4R,5R)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 18-crown-6-ether; KN(TMS)2 / tetrahydrofuran; toluene / 0.25 h / -78 °C

1.2: 52 percent / tetrahydrofuran; toluene / 0.75 h / -78 °C

2.1: 81 percent / DIBAL-H / CH₂Cl₂; hexane / 0.33 h / -78 °C

3.1: TiCl₄; molecular sieves 4 Angstroem / 1,2-dichloro-ethane / 20 °C

With 18-crown-6 ether; 4 A molecular sieve; titanium tetrachloride; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo001015i

Reference yield:

: 112980-49-1
(Z)-(S)-4-(tert-butyldimethylsilanyloxy)pent-2-enoic acid methyl ester

: 342638-17-9
(1R,4R,5R)-4-[(S)-1-(tert-butyldimethylsilyloxy)ethyl]-2-phenylmethyl-3,7-dioxa-2-azabicyclo[3.3.0]octan-8-one

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / DIBAL-H / CH₂Cl₂; hexane / 0.33 h / -78 °C

2: TiCl₄; molecular sieves 4 Angstroem / 1,2-dichloro-ethane / 20 °C

With 4 A molecular sieve; titanium tetrachloride; diisobutylaluminium hydride; In hexane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo001015i