N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Base Information

Chemical Name:N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide
CAS No.:915036-67-8
Molecular Formula:C₂₀H₂₂N₄S
Molecular Weight:350.487
Hs Code.:

Synonyms:N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

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Chemical Property of N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

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Technology Process of N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

There total 8 articles about N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: tert-butyl methyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate

: 915036-67-8
N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Guidance literature:: tert-butyl methyl(4-(5-(thiophene-2-carboximidamido)-1H-indol-3-yl)cyclohex-3-enyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

With ammonia; In water;

Reference yield:

: 915037-56-8
tert-butyl methyl(4-(5-nitro-1H-indol-3-yl)cyclohex-3-enyl)carbamate

: 915036-67-8
N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 0.5 h / Inert atmosphere; Reflux

2: ethanol / 24 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

With hydrazine hydrate; trifluoroacetic acid; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm300138g

Reference yield:

: 915037-55-7
N-methyl-4-(5-nitro-1H-indol-3-yl)cyclohex-3-enamine

: 915036-67-8
N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

2: hydrazine hydrate / methanol / 0.5 h / Inert atmosphere; Reflux

3: ethanol / 24 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

With hydrazine hydrate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1021/jm300138g