(R)-1-(2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl)cyclohexanol (R)-1-phenyl-1-cyclohexyl-1-hydroxyacetic acid salt

Base Information

Chemical Name:(R)-1-(2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl)cyclohexanol (R)-1-phenyl-1-cyclohexyl-1-hydroxyacetic acid salt
CAS No.:1049701-07-6
Molecular Formula:C₁₄H₁₈O₃*C₁₆H₂₅NO₂
Molecular Weight:497.675
Hs Code.:

Synonyms:(R)-1-(2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl)cyclohexanol (R)-1-phenyl-1-cyclohexyl-1-hydroxyacetic acid salt

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Chemical Property of (R)-1-(2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl)cyclohexanol (R)-1-phenyl-1-cyclohexyl-1-hydroxyacetic acid salt

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Technology Process of (R)-1-(2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl)cyclohexanol (R)-1-phenyl-1-cyclohexyl-1-hydroxyacetic acid salt

There total 1 articles about (R)-1-(2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl)cyclohexanol (R)-1-phenyl-1-cyclohexyl-1-hydroxyacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93413-69-5
1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol

: 1049701-07-6
(R)-1-(2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl)cyclohexanol (R)-1-phenyl-1-cyclohexyl-1-hydroxyacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diphenylphosphide / tetrahydrofuran / 0 - 20 °C / Heating / reflux

1.2: 0.17 h / 15 °C

1.3: pH 6.8 - 6.9

2.1: ethanol; water / 0.5 h / 75 °C / Resolution of racemate

With lithium diphenylphosphide; In tetrahydrofuran; ethanol; water;

Reference yield:

: 1049701-07-6
(R)-1-(2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl)cyclohexanol (R)-1-phenyl-1-cyclohexyl-1-hydroxyacetic acid salt

: 1049700-94-8
(-)-O-desmethylvenlafaxine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; tert-butyl methyl ether; water; at 20 - 40 ℃; for 4h; Product distribution / selectivity;