5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol

Base Information

• Chemical Name: 5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol
• CAS No.: 913636-45-0
• Molecular Formula: C₂₂H₂₉N₃O₃Si
• Molecular Weight: 411.576

Synonyms:5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol

Chemical Property of 5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol

There total 8 articles about 5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

tert-Butyl-[(S)-1-(3,7-dioxa-bicyclo[4.1.0]hept-4-yl)methoxy]-diphenyl-silane (913636-43-8) → 5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol (913636-45-0)

Guidance literature:

With sodium azide; ammonium chloride; In ethanol; water; at 80 ℃; for 9h;

DOI:10.1016/j.tetlet.2006.08.006

Reference yield:

(S)-2-(allyloxy)pent-4-enal → 5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol (913636-45-0)

Guidance literature:

Multi-step reaction with 5 steps

1: NaBH₄ / methanol / 0.25 h

2: 85 percent / imidazole / tetrahydrofuran / 2 h / 0 °C

3: 80 percent / Grubbs' 1st generation catalyst / CH₂Cl₂ / 6 h / 20 °C

4: 62 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 6 h

5: 58 percent / NaN₃; NH₄Cl / ethanol; H₂O / 9 h / 80 °C

With 1H-imidazole; sodium tetrahydroborate; sodium azide; sodium hydrogencarbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; Grubbs catalyst first generation; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

DOI:10.1016/j.tetlet.2006.08.006

Reference yield:

(R)-3-Allyloxy-hex-5-ene-1,2-diol → 5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol (913636-45-0)

Guidance literature:

Multi-step reaction with 6 steps

1: NaIO₄; NaHCO₃ / CH₂Cl₂ / 8 h / 0 - 20 °C

2: NaBH₄ / methanol / 0.25 h

3: 85 percent / imidazole / tetrahydrofuran / 2 h / 0 °C

4: 80 percent / Grubbs' 1st generation catalyst / CH₂Cl₂ / 6 h / 20 °C

5: 62 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 6 h

6: 58 percent / NaN₃; NH₄Cl / ethanol; H₂O / 9 h / 80 °C

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; sodium azide; sodium hydrogencarbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; Grubbs catalyst first generation; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

DOI:10.1016/j.tetlet.2006.08.006

upstream raw materials:

tert-Butyl-[(S)-1-(3,7-dioxa-bicyclo[4.1.0]hept-4-yl)methoxy]-diphenyl-silane

(S)-2-(allyloxy)pent-4-en-1-ol

(S)-dihydropyranylmethoxy(tert-butyl)diphenylsilane

(2-allyloxy-pent-4-enyloxy)-tert-butyl-diphenyl-silane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 913636-45-0 5-azido-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-4-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send