Technology Process of (2R,3R)-1,4-bis[(4S)-4-isopropyl-2-oxo(1,3-oxazolidin-3-yl)]-2,3-bisbenzylbutane-1,4-dione
There total 3 articles about (2R,3R)-1,4-bis[(4S)-4-isopropyl-2-oxo(1,3-oxazolidin-3-yl)]-2,3-bisbenzylbutane-1,4-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
titanium tetrachloride; lithium diisopropyl amide;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00110a003
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere; Sealed tube; Schlenk technique
1.2: 2.5 h / -78 °C
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.67 h / -78 °C / Schlenk technique; Inert atmosphere; Sealed tube
2.2: 21 h / 20 °C
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere; Sealed tube; Schlenk technique
1.2: 2.5 h / -78 °C
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.67 h / -78 °C / Schlenk technique; Inert atmosphere; Sealed tube
2.2: 21 h / 20 °C
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
