Technology Process of C24H24ClN5O2*ClH
There total 5 articles about C24H24ClN5O2*ClH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-methoxy-4-(2-methylpyridin-4-yl)aniline; 3-bromo-5-(2-chlorophenoxy)-1-(propan-2-yl)-1H-1,2,4-triazole;
With
caesium carbonate; XPhos;
tris-(dibenzylideneacetone)dipalladium(0);
In
tert-butyl alcohol;
at 100 ℃;
for 16h;
Inert atmosphere;
With
hydrogenchloride;
In
di-isopropyl ether; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 16 h / Reflux
2: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 50 °C
3: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium(0) / tert-butyl alcohol / 16 h / 100 °C / Inert atmosphere
With
thiophene; hydrogen; caesium carbonate; XPhos;
tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
methanol; 1,2-dimethoxyethane; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 16 h / Reflux
2: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 50 °C
3: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium(0) / tert-butyl alcohol / 16 h / 100 °C / Inert atmosphere
With
thiophene; hydrogen; caesium carbonate; XPhos;
tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
methanol; 1,2-dimethoxyethane; water; tert-butyl alcohol;