4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl diethyl phosphate

Base Information

• Chemical Name: 4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl diethyl phosphate
• CAS No.: 1552270-27-5
• Molecular Formula: C₁₇H₁₈Cl₂NO₅P
• Molecular Weight: 418.213
• Mol file: 1552270-27-5.mol

Synonyms:4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl diethyl phosphate

Chemical Property of 4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl diethyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl diethyl phosphate

There total 2 articles about 4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl diethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4',5-dichlorosalicylanilide (1147-98-4) + diethyl chlorophosphate (814-49-3) → 4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl diethyl phosphate (1552270-27-5)

Guidance literature:

4',5-dichlorosalicylanilide; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

diethyl chlorophosphate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2013.12.016

Reference yield:

5-chloro-2-hydroxybenzoic acid (321-14-2) + 4-chloro-aniline (106-47-8) → 4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl diethyl phosphate (1552270-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus trichloride / Microwave irradiation

2.1: triethylamine / dichloromethane / 0.08 h / 20 °C

2.2: 2 h / 20 °C

With triethylamine; phosphorus trichloride; In dichloromethane;

DOI:10.1016/j.bmc.2013.12.016

upstream raw materials:

4',5-dichlorosalicylanilide

diethyl chlorophosphate

5-chloro-2-hydroxybenzoic acid

4-chloro-aniline