benzyl [(5S)-6-oxo-6,7-dihydro-5H-pyrrolo[1,2-d][1,4]benzodiazepin-5-yl]acetate

Base Information

• Chemical Name: benzyl [(5S)-6-oxo-6,7-dihydro-5H-pyrrolo[1,2-d][1,4]benzodiazepin-5-yl]acetate
• CAS No.: 147528-08-3
• Molecular Formula: C₂₁H₁₈N₂O₃
• Molecular Weight: 346.386
• Mol file: 147528-08-3.mol

Synonyms:5H-Pyrrolo[1,2-d][1,4]benzodiazepine-5-aceticacid, 6,7-dihydro-6-oxo-, phenylmethyl ester, (S)-

Chemical Property of benzyl [(5S)-6-oxo-6,7-dihydro-5H-pyrrolo[1,2-d][1,4]benzodiazepin-5-yl]acetate

Chemical Property:

• Vapor Pressure: 7.35E-14mmHg at 25°C
• Boiling Point: 589.2°C at 760 mmHg
• Flash Point: 310.1°C
• Density: 1.26g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl [(5S)-6-oxo-6,7-dihydro-5H-pyrrolo[1,2-d][1,4]benzodiazepin-5-yl]acetate

There total 7 articles about benzyl [(5S)-6-oxo-6,7-dihydro-5H-pyrrolo[1,2-d][1,4]benzodiazepin-5-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(RS)-benzyl 2-(5-(but-3-en-1-yl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate → (S)-benzyl 2-(6-oxo-6,7-dihydro-5H-benzo[f]pyrrolo[1,2-d][1,4]diazepin-5-yl)acetate (147528-08-3)

Guidance literature:

(RS)-benzyl 2-(5-(but-3-en-1-yl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate; With ozone; In methanol; dichloromethane; at -78 ℃;

With dimethylsulfide; In methanol; dichloromethane; at -78 ℃; for 30h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01679

Reference yield:

(RS)-benzyl 2-(5-(but-3-en-1-yl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate → (R)-benzyl 2-(6-oxo-6,7-dihydro-5H-benzo[f]pyrrolo[1,2-d][1,4]diazepin-5-yl)acetate (147528-08-3) + (S)-benzyl 2-(6-oxo-6,7-dihydro-5H-benzo[f]pyrrolo[1,2-d][1,4]diazepin-5-yl)acetate (147528-08-3)

Guidance literature:

(RS)-benzyl 2-(5-(but-3-en-1-yl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate; With ozone; In methanol; dichloromethane; at -78 ℃;

With dimethylsulfide; In methanol; dichloromethane; at -78 ℃; for 30h; Overall yield = 52 %; Overall yield = 23 mg; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01679

Reference yield:

(RS)-benzyl 2-(5-(but-3-en-1-yl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate → (R)-benzyl 2-(6-oxo-6,7-dihydro-5H-benzo[f]pyrrolo[1,2-d][1,4]diazepin-5-yl)acetate (147528-08-3) + (S)-benzyl 2-(6-oxo-6,7-dihydro-5H-benzo[f]pyrrolo[1,2-d][1,4]diazepin-5-yl)acetate (147528-08-3)

Guidance literature:

(RS)-benzyl 2-(5-(but-3-en-1-yl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate; With ozone; In methanol; dichloromethane; at -78 ℃;

With dimethylsulfide; In methanol; dichloromethane; at -78 ℃; for 30h; Overall yield = 52 %; Overall yield = 23 mg; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01679

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