2-chloro-8-(3,3-difluoro-cyclobutyl)-6-methyl-5,6,7,8-tetrahydro-9-oxa-1,6-diaza-benzocycloheptene

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Chemical Name:2-chloro-8-(3,3-difluoro-cyclobutyl)-6-methyl-5,6,7,8-tetrahydro-9-oxa-1,6-diaza-benzocycloheptene
CAS No.:1375710-65-8
Molecular Formula:C₁₃H₁₅ClF₂N₂O
Molecular Weight:288.725
Hs Code.:

Synonyms:2-chloro-8-(3,3-difluoro-cyclobutyl)-6-methyl-5,6,7,8-tetrahydro-9-oxa-1,6-diaza-benzocycloheptene

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Chemical Property of 2-chloro-8-(3,3-difluoro-cyclobutyl)-6-methyl-5,6,7,8-tetrahydro-9-oxa-1,6-diaza-benzocycloheptene

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Technology Process of 2-chloro-8-(3,3-difluoro-cyclobutyl)-6-methyl-5,6,7,8-tetrahydro-9-oxa-1,6-diaza-benzocycloheptene

There total 2 articles about 2-chloro-8-(3,3-difluoro-cyclobutyl)-6-methyl-5,6,7,8-tetrahydro-9-oxa-1,6-diaza-benzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20249-16-5
3-oxo-cyclobutanecarbonitrile

: 1375710-65-8
2-chloro-8-(3,3-difluoro-cyclobutyl)-6-methyl-5,6,7,8-tetrahydro-9-oxa-1,6-diaza-benzocycloheptene

Guidance literature:: Multi-step reaction with 10 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / -10 - 20 °C

2.1: sodium hydroxide; water / pentane; methanol / 75 h / 20 - 60 °C

2.2: pH 1

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

4.2: 0 °C

5.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 73 h / 0 - 20 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C / 2327.23 Torr

8.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

9.1: sodium hydride / tetrahydrofuran / 0 - 40 °C

10.1: methanol / 6 h / 20 °C

10.2: 20 °C

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; water; hydrogen; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; pentane;

Reference yield:

: 15760-35-7
3-methylenecyclobutanecarbonitrile

: 1375710-65-8
2-chloro-8-(3,3-difluoro-cyclobutyl)-6-methyl-5,6,7,8-tetrahydro-9-oxa-1,6-diaza-benzocycloheptene

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium periodate / ruthenium(III) trichloride hydrate / dichloromethane; acetonitrile; water / 5 - 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / -10 - 20 °C

3.1: sodium hydroxide; water / pentane; methanol / 75 h / 20 - 60 °C

3.2: pH 1

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

5.2: 0 °C

6.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 73 h / 0 - 20 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C / 2327.23 Torr

9.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

10.1: sodium hydride / tetrahydrofuran / 0 - 40 °C

11.1: methanol / 6 h / 20 °C

11.2: 20 °C

With sodium periodate; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; water; hydrogen; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; sodium hydroxide; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; pentane;