GASTRIN RELEASING PEPTIDE, HUMAN

Base Information

• Chemical Name: GASTRIN RELEASING PEPTIDE, HUMAN
• CAS No.: 93755-85-2
• Molecular Formula: C130H204N38O31S2
• Molecular Weight: 2859.38

Synonyms:Gastrin-releasingpeptide (pig), 1-L-valine-3-L-leucine-4-L-proline-5-L-alanine-12-L-threonine-;93: PN: US20060293232 PAGE: 15 unclaimed sequence;Human gastrin releasingpeptide (1-27);Human gastrin-releasing peptide;L-Methioninamide,L-valyl-L-prolyl-L-leucyl-L-prolyl-L-alanylglycylglycylglycyl-L-threonyl-L-valyl-L-leucyl-L-threonyl-L-lysyl-L-methionyl-L-tyrosyl-L-prolyl-L-arginylglycyl-L-asparaginyl-L-histidyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-;[1-27]-Human gastrin-releasing peptide;Gastrin-Releasing Peptide, human;

Chemical Property of GASTRIN RELEASING PEPTIDE, HUMAN

Chemical Property:

• PSA: 0.00000
• Density: 1.46±0.1 g/cm3(Predicted)
• LogP: 0.00000
• Storage Temp.: −20°C

Purity/Quality:

99%, ^*data from raw suppliers

GRP(human) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Biological functions: GRP functions via GRPR, which is highly expressed in the pancreas, and is also expressed in the stomach, adrenal cortex, and brain. Considerable evidence indicates that GRP plays a role in many physiological processes, including food intake, male sexual functions,circadian rhythms, sigh control, and fear-memory consolidation in the mammalian CNS. In addition, the itch sensation is a major biological function of GRP in mammals. In chicks, GRP functions as an anorexigenic factor in the brain.
• Description: Gut-brain peptides are widely conserved in vertebrates, GRP is a neuropeptide that modulates the autonomic system. It is an anorexigenic factor in the brain, regulates male sexual function at the spinal cord level, conveys the itch sensation, and is also involved in many autonomic regulations in the brain. The expression of GRP is also a specific tumor marker for small cell lung cancer. It has the GXHWAVGHLM amide (X=N or S) sequence at its C-terminus.
• Uses: GRP (gastrin releasing peptide) has been used for absorption/neutralization of anti-GRP antibody prior to the tyramide signal amplification (TSA) procedure.
• Clinical Use: GRP mRNA is overexpressed in patients suffering from small cell lung cancer. Clinically, therefore, a higher level of circulating proGRP31–125 is a specific tumor marker for small cell lung cancer (higher than ~81.0 pg/mL in the plasma). In addition, intravenous infusions of GRP decrease spontaneous food intake in healthy men, suggesting GRP acts as a satiety signal in humans. GRP has not yet been used much clinically as a therapeutic agent.

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