(S)-N-{8-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-3-yl}-2-benzyloxy-acetamide

Base Information

Chemical Name:(S)-N-{8-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-3-yl}-2-benzyloxy-acetamide
CAS No.:741723-24-0
Molecular Formula:C₂₇H₂₉N₅O₅
Molecular Weight:503.558
Hs Code.:

Synonyms:(S)-N-{8-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-3-yl}-2-benzyloxy-acetamide

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Chemical Property of (S)-N-{8-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-3-yl}-2-benzyloxy-acetamide

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Technology Process of (S)-N-{8-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-3-yl}-2-benzyloxy-acetamide

There total 4 articles about (S)-N-{8-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-3-yl}-2-benzyloxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 741723-23-9
(S)-N-[3-(3-amino-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-8-yl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

: 30379-55-6
benzyloxyacetic acid

: 741723-24-0
(S)-N-{8-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-3-yl}-2-benzyloxy-acetamide

Guidance literature:: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1016/j.bmcl.2007.05.085

Reference yield:

: 740842-18-6
(S)-N-[2-oxo-3-(5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-oxazolidin-5-ylmethyl]-acetamide

: 741723-24-0
(S)-N-{8-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-3-yl}-2-benzyloxy-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / pyridinium tribromide; AcOH / CH₂Cl₂ / 20 °C

2: ethanol / 88 °C

3: 87 percent / Et₃SiH; TFA / CH₂Cl₂

4: 47 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; pyridine

With pyridine; triethylsilane; acetic acid; pyridinium hydrobromide perbromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.05.085

Reference yield:

: 740842-24-4
C₁₇H₁₉BrN₂O₄

: 741723-24-0
(S)-N-{8-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-3-yl}-2-benzyloxy-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 88 °C

2: 87 percent / Et₃SiH; TFA / CH₂Cl₂

3: 47 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; pyridine

With pyridine; triethylsilane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.05.085