methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

Base Information

Chemical Name:methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate
CAS No.:157478-19-8
Molecular Formula:C₃₃H₃₃N₃O₉
Molecular Weight:615.64
Hs Code.:

methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

Synonyms:methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

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Chemical Property of methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

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Technology Process of methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

There total 5 articles about methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132628-67-2,132628-68-3
methyl (2S*,8S*)-4-benzyloxy-6-t-butoxycarbonyl-8-(t-butyldimethylsilyloxy)methyl-3-formyl-1,2,3,6,7,8-hexahydro-2-methyl-1-oxobenzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

: 157478-19-8
methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / 10percent citric acid / acetic acid / 10 h / Ambient temperature

2: 46 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-dimethylaminopyridine / CH₂Cl₂ / 4 h / Ambient temperature

3: 98 percent / K₂CO₃ / methanol / 1 h / Ambient temperature

4: 10percent HCl / methanol / Ambient temperature

5: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, NaHCO₃ / dimethylformamide / Ambient temperature

With hydrogenchloride; dmap; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; citric acid; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86994-5

Reference yield:

: 149405-57-2
methyl (2R,8R)-8-<(S)-(1-acetoxy-1-phenyl)acetoxy>methyl-4-benzyloxy-6-t-butoxycarbonyl-3-formyl-1,2,3,6,7,8-hexahydro-2-methyl-1-oxobenzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

: 157478-19-8
methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / K₂CO₃ / methanol / 1 h / Ambient temperature

2: 10percent HCl / methanol / Ambient temperature

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, NaHCO₃ / dimethylformamide / Ambient temperature

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86994-5

Reference yield:

: 157478-17-6
methyl (2R,8R)-4-benzyloxy-6-t-butoxycarbonyl-3-formyl-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxobenzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

: 157478-19-8
methyl (2R,8R)-4-benzyloxy-1,2,3,6,7,8-hexahydro-8-hydroxymethyl-2-methyl-1-oxo-6-<(5,6,7-trimethoxy-1H-indole-2-yl)carbonyl>benzo<1,2-b;4,3-b'>dipyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 10percent HCl / methanol / Ambient temperature

2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, NaHCO₃ / dimethylformamide / Ambient temperature

With hydrogenchloride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86994-5