(2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Base Information

• Chemical Name: (2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone
• CAS No.: 1332526-30-3
• Molecular Formula: C₂₅H₂₁BrN₂O₆S
• Molecular Weight: 557.422

Synonyms:(2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Chemical Property of (2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Chemical Property:

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Technology Process of (2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

There total 2 articles about (2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazole (1332526-28-9) + 3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → (2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (1332526-30-3)

Guidance literature:

2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazole; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.166667h; Inert atmosphere;

3,4,5-Trimethoxybenzoyl chloride; In tetrahydrofuran; pentane; at -78 ℃;

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → (2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (1332526-30-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonium hydroxide / ethanol; water / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / Inert atmosphere

3.2: -78 °C / Inert atmosphere

With ammonium hydroxide; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; ethanol; water; mineral oil; pentane;

DOI:10.1016/j.bmc.2011.06.084

Reference yield: 80.0%

(2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (1332526-30-3) → (2-(4-bromophenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (1332526-32-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2011.06.084

upstream raw materials:

2-(4-bromophenyl)-1-(phenylsulfonyl)-1H-imidazole

3,4,5-Trimethoxybenzoyl chloride

4-bromo-benzaldehyde

Downstream raw materials:

(2-(4-bromophenyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

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