(2R^*,6R^*)-2,6-Bis<(2R^*)-2-acetoxy-4-(3-iodo-4-methoxyphenyl)butyl>-1-benzoylpiperidine

Base Information

• Chemical Name: (2R^*,6R^*)-2,6-Bis<(2R^*)-2-acetoxy-4-(3-iodo-4-methoxyphenyl)butyl>-1-benzoylpiperidine
• CAS No.: 134721-16-7
• Molecular Formula: C₃₈H₄₅I₂NO₇
• Molecular Weight: 881.587
• Mol file: 134721-16-7.mol

Synonyms:(2R^*,6R^*)-2,6-Bis<(2R^*)-2-acetoxy-4-(3-iodo-4-methoxyphenyl)butyl>-1-benzoylpiperidine

Chemical Property of (2R^*,6R^*)-2,6-Bis<(2R^*)-2-acetoxy-4-(3-iodo-4-methoxyphenyl)butyl>-1-benzoylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R^*,6R^*)-2,6-Bis<(2R^*)-2-acetoxy-4-(3-iodo-4-methoxyphenyl)butyl>-1-benzoylpiperidine

There total 10 articles about (2R^*,6R^*)-2,6-Bis<(2R^*)-2-acetoxy-4-(3-iodo-4-methoxyphenyl)butyl>-1-benzoylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(2R*,6R*)-2,6-Bis<(2R*)-2-acetoxy-4-(p-methoxyphenyl)butyl>-1-benzoylpiperidine (134721-15-6) → (2R*,6R*)-2,6-Bis<(2R*)-2-acetoxy-4-(3-iodo-4-methoxyphenyl)butyl>-1-benzoylpiperidine (134721-16-7)

Guidance literature:

With iodine; silver trifluoroacetate; In dichloromethane; chloroform; for 3h; Ambient temperature;

Reference yield:

N-hydroxypiperidine (4801-58-5) → (2R*,6R*)-2,6-Bis<(2R*)-2-acetoxy-4-(3-iodo-4-methoxyphenyl)butyl>-1-benzoylpiperidine (134721-16-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 1. HgO (yellow) / 1. CH₂Cl₂, 30min, 2. CHCl₃, reflux, 24h

2: 1. m-chloroperoxybenzoic acid (MCPBA) / 1. CHCl₂, r.t., 1h; 2. CHCl₃, reflux, 40h

3: 74 percent / Zn, ethylenediaminetetraacetic acid / acetic acid; ethanol / 0.5 h / Heating

4: 31 percent / triethylamine / benzene / 8 h

5: methanolic KOH

6: 96 percent / pyridine / 4-Dimethylaminopyridine (DMAP) / 24 h

7: H₂ / 5percent Pd/C / methanol; diethyl ether / 1.5 h / 760 Torr

8: K₂CO₃ / acetone / 4 h / Heating

9: 83 percent / I₂, silver trifluoroacetate / CH₂Cl₂; CHCl₃ / 3 h / Ambient temperature

With pyridine; potassium hydroxide; ethylenediaminetetraacetic acid; hydrogen; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; mercury(II) oxide; zinc; dmap; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dichloromethane; chloroform; acetic acid; acetone; benzene;

Reference yield:

1-(benzyloxy)-4-(but-3-en-1-yl)benzene (134721-17-8) → (2R*,6R*)-2,6-Bis<(2R*)-2-acetoxy-4-(3-iodo-4-methoxyphenyl)butyl>-1-benzoylpiperidine (134721-16-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 1. HgO (yellow) / 1. CH₂Cl₂, 30min, 2. CHCl₃, reflux, 24h

2: 1. m-chloroperoxybenzoic acid (MCPBA) / 1. CHCl₂, r.t., 1h; 2. CHCl₃, reflux, 40h

3: 74 percent / Zn, ethylenediaminetetraacetic acid / acetic acid; ethanol / 0.5 h / Heating

4: 31 percent / triethylamine / benzene / 8 h

5: methanolic KOH

6: 96 percent / pyridine / 4-Dimethylaminopyridine (DMAP) / 24 h

7: H₂ / 5percent Pd/C / methanol; diethyl ether / 1.5 h / 760 Torr

8: K₂CO₃ / acetone / 4 h / Heating

9: 83 percent / I₂, silver trifluoroacetate / CH₂Cl₂; CHCl₃ / 3 h / Ambient temperature

With pyridine; potassium hydroxide; ethylenediaminetetraacetic acid; hydrogen; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; mercury(II) oxide; zinc; dmap; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dichloromethane; chloroform; acetic acid; acetone; benzene;

upstream raw materials:

(2R^*,6R^*)-2,6-Bis<(2R^*)-2-acetoxy-4-(p-methoxyphenyl)butyl>-1-benzoylpiperidine

N-hydroxypiperidine

1-(benzyloxy)-4-(but-3-en-1-yl)benzene

trans-8-<2-(p-Benzyloxyphenyl)ethyl>-9-oxa-1-azabicyclo<4.3.0>nonane

Downstream raw materials:

(2R^*,6R^*)-2,6-Bis<(2R^*)-2-acetoxy-4-(p-methoxyphenyl)butyl>-1-benzoylpiperidine

C₃₈H₄₅NO₇

3,11-epi-Lythranidine

C₃₄H₄₁NO₅