(S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

Base Information

• Chemical Name: (S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid
• CAS No.: 164263-06-3
• Molecular Formula: C₂₁H₂₃Cl₂NO₆
• Molecular Weight: 456.323
• Mol file: 164263-06-3.mol

Synonyms:(S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

Chemical Property of (S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

There total 2 articles about (S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid bis-(2,2-dimethyl-propionyloxymethyl) ester → (S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid (164263-06-3)

Guidance literature:

With water; In di-isopropyl ether; for 360h; lipase AH;

DOI:10.1248/cpb.42.1968

Reference yield:

4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-tert-butoxycarbonylmethyl ester 5-(2,2-dimethyl-propionyloxymethyl) ester → (S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid (164263-06-3) + (R)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid (164263-08-5)

Guidance literature:

With lipase AH; In cyclohexane; for 95h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1248/cpb.45.869

Reference yield:

(S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid (164263-06-3) → (S)-Felodipine (105618-03-9,86189-69-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) OH^(1-)

2: thionyl chloride

With thionyl chloride; hydroxide;

DOI:10.1248/cpb.42.1968

Downstream raw materials:

(R)-(+)-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylic acid

(S)-Felodipine