Technology Process of 3-ethyl-12-(toluene-4-sulfonyl)-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine
There total 9 articles about 3-ethyl-12-(toluene-4-sulfonyl)-1,4,6,7,12,12b-hexahydro-indolo[2,3-a]quinolizine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
toluene;
at 80 ℃;
for 3h;
DOI:10.1016/j.tetlet.2006.10.106
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84 percent / NaOH; TBAHSO4 / benzene / 0.33 h / 20 °C
2: DIBAL-H / CH2Cl2 / 2 h / -78 °C
3: tetrahydrofuran / 12 h / 20 °C
4: 87 percent / Grubbs' 2nd. generation catalyst / toluene / 3 h / 80 °C
With
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; diisobutylaluminium hydride;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; dichloromethane; toluene; benzene;
3: Wittig olefination;
DOI:10.1016/j.tetlet.2006.10.106
- Guidance literature:
-
Multi-step reaction with 3 steps
1: DIBAL-H / CH2Cl2 / 2 h / -78 °C
2: tetrahydrofuran / 12 h / 20 °C
3: 87 percent / Grubbs' 2nd. generation catalyst / toluene / 3 h / 80 °C
With
diisobutylaluminium hydride;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; dichloromethane; toluene;
2: Wittig olefination;
DOI:10.1016/j.tetlet.2006.10.106
