(S)-3-{4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenoxy}propane-1,2-diol

Base Information

Chemical Name:(S)-3-{4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenoxy}propane-1,2-diol
CAS No.:1262414-35-6
Molecular Formula:C₂₅H₃₁N₃O₅
Molecular Weight:453.538
Hs Code.:

Synonyms:(S)-3-{4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenoxy}propane-1,2-diol

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Chemical Property of (S)-3-{4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenoxy}propane-1,2-diol

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Technology Process of (S)-3-{4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenoxy}propane-1,2-diol

There total 9 articles about (S)-3-{4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenoxy}propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262414-37-8
4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenol

: 60827-45-4
(S)-3-chloropropan-1,2-diol

: 1262414-35-6
(S)-3-{4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenoxy}propane-1,2-diol

Guidance literature:: With sodium hydroxide; In water; isopropyl alcohol; at 70 ℃; for 48h;

Reference yield:

: 944327-05-3
4-benzyloxy-3-ethyl-5-methylbenzoic acid

: 1262414-35-6
(S)-3-{4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenoxy}propane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 1 h / 20 °C

2: Burgess Reagent / tetrahydrofuran / 0.25 h / 110 °C / Microwave irradiation

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 24 h / 20 °C / 750.08 Torr

4: sodium hydroxide / isopropyl alcohol; water / 48 h / 70 °C

With Burgess Reagent; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 944327-07-5
4-benzyloxy-3-ethyl-5-methylbenzaldehyde

: 1262414-35-6
(S)-3-{4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)[1,3,4]oxadiazol-2-yl]-2-ethyl-6-methylphenoxy}propane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate dihydrate / water; tert-butyl alcohol / 30 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 1 h / 20 °C

3: Burgess Reagent / tetrahydrofuran / 0.25 h / 110 °C / Microwave irradiation

4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 24 h / 20 °C / 750.08 Torr

5: sodium hydroxide / isopropyl alcohol; water / 48 h / 70 °C

With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; Burgess Reagent; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; tert-butyl alcohol;