2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-pent-4-enyl ester

Base Information

• Chemical Name: 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-pent-4-enyl ester
• CAS No.: 202275-19-2
• Molecular Formula: C₂₇H₃₆N₂O₃
• Molecular Weight: 436.594

Synonyms:2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-pent-4-enyl ester

Chemical Property of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-pent-4-enyl ester

Chemical Property:

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Technology Process of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-pent-4-enyl ester

There total 2 articles about 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-pent-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-4-hydroxy-butyl ester (202275-17-0) → 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-pent-4-enyl ester (202275-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2: t-BuOK / tetrahydrofuran / 1 h / Heating

With oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-1997-1382

Reference yield:

Methylenetriphenylphosphorane (19493-09-5) + 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-4-oxo-butyl ester → 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-pent-4-enyl ester (202275-19-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 1h; Yield given; Heating;

DOI:10.1055/s-1997-1382

Reference yield: 98.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-pent-4-enyl ester (202275-19-2) → 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-3-cyclopropyl-2-dibenzylamino-propyl ester

Guidance literature:

With palladium diacetate; In diethyl ether; for 12h; Ambient temperature;

DOI:10.1055/s-1997-1382

upstream raw materials:

Methylenetriphenylphosphorane

2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-4-hydroxy-butyl ester

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