ethyl 1-cyclopropyl-8-(4-fluorophenyl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Base Information

Chemical Name:ethyl 1-cyclopropyl-8-(4-fluorophenyl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylate
CAS No.:1371630-41-9
Molecular Formula:C₂₂H₂₀FNO₃
Molecular Weight:365.404
Hs Code.:

Synonyms:ethyl 1-cyclopropyl-8-(4-fluorophenyl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

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Chemical Property of ethyl 1-cyclopropyl-8-(4-fluorophenyl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Chemical Property:

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Technology Process of ethyl 1-cyclopropyl-8-(4-fluorophenyl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

There total 8 articles about ethyl 1-cyclopropyl-8-(4-fluorophenyl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 335428-52-9
ethyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

: 1765-93-1
4-fluoroboronic acid

: 1371630-41-9
ethyl 1-cyclopropyl-8-(4-fluorophenyl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; at 80 ℃; Inert atmosphere;

Reference yield:

: (3-methyl-4-chloropyridin-2-yl)cyclopropylmethanol

: 1371630-41-9
ethyl 1-cyclopropyl-8-(4-fluorophenyl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 °C

2.2: 40 °C

3.1: sulfuric acid; acetic acid / 20 °C

3.2: pH 8 - 9

4.1: piperidine; acetic acid / ethanol / Reflux

5.1: diphenyl ether-biphenyl eutectic / 0.25 h / 230 °C

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 80 °C / Inert atmosphere

With piperidine; manganese(IV) oxide; sulfuric acid; sodium hydride; sodium carbonate; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; diphenyl ether-biphenyl eutectic; ethanol; dichloromethane; water; mineral oil;

Reference yield:

: 335428-51-8
2-(3-methyl-4-chloropyridin-2-yl)-2-cyclopropylacetaldehyde

: 1371630-41-9
ethyl 1-cyclopropyl-8-(4-fluorophenyl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine; acetic acid / ethanol / Reflux

2: diphenyl ether-biphenyl eutectic / 0.25 h / 230 °C

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 80 °C / Inert atmosphere

With piperidine; sodium carbonate; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; diphenyl ether-biphenyl eutectic; ethanol; water;