O-benzyl-ciprofloxacin hydrochloride

Base Information

• Chemical Name: O-benzyl-ciprofloxacin hydrochloride
• CAS No.: 1422350-03-5
• Molecular Formula: C₂₄H₂₄FN₃O₃*ClH
• Molecular Weight: 457.932
• Mol file: 1422350-03-5.mol

Synonyms:O-benzyl-ciprofloxacin hydrochloride

Chemical Property of O-benzyl-ciprofloxacin hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-benzyl-ciprofloxacin hydrochloride

There total 3 articles about O-benzyl-ciprofloxacin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl 7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate → O-benzyl-ciprofloxacin hydrochloride (1422350-03-5)

Guidance literature:

With hydrogenchloride; water; In dichloromethane; for 0.666667h; Inert atmosphere;

DOI:10.1021/bc300610f

Reference yield:

ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) → O-benzyl-ciprofloxacin hydrochloride (1422350-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 25.5 h / 90 °C / Inert atmosphere

3: hydrogenchloride; water / dichloromethane / 0.67 h / Inert atmosphere

With hydrogenchloride; water; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/bc300610f

Reference yield:

7-[4-tert-butoxycarbonyl-piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (93594-48-0) → O-benzyl-ciprofloxacin hydrochloride (1422350-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 25.5 h / 90 °C / Inert atmosphere

2: hydrogenchloride; water / dichloromethane / 0.67 h / Inert atmosphere

With hydrogenchloride; water; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/bc300610f

upstream raw materials:

7-[4-tert-butoxycarbonyl-piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

ciprofloxacin

Downstream raw materials:

C₆₃H₇₃FN₆O₁₀

C₇₉H₉₅FN₈O₁₃

C₄₇H₅₁FN₄O₇

C₉₃H₉₉FN₈O₁₄