(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide
CAS No.:1428846-95-0
Molecular Formula:C₃₀H₃₀Cl₂F₂N₂O₈S₂
Molecular Weight:719.612
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide

There total 10 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.4%

: 1428846-77-8
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-nitrophenoxy)carbonyloxy)-ethyl)pyridine 1-oxide

: 1428846-99-4
N-(2-(cyclopropylmethoxy)-4-mercaptophenyl)-methanesulfonamide

: 1428846-95-0
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 1428846-95-0
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / acetonitrile / 85 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 1034.32 Torr

3: pyridine / 2 h / 0 - 20 °C

4: nitric acid / 1 h / 0 - 20 °C

5: iron; ammonium chloride / ethanol; water / 0.5 h / Reflux

6: hydrogenchloride; sodium nitrite / water / 0.25 h / 5 - 10 °C

7: water / 0.25 h / 65 °C

8: sodium tetrahydroborate; potassium hydroxide / methanol / 2 h / 20 °C

9: dmap / dichloromethane / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; nitric acid; iron; potassium carbonate; ammonium chloride; potassium hydroxide; sodium nitrite; In pyridine; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 21315-09-3
1-(cyclopropylmethoxy)-2-nitrobenzene

: 1428846-95-0
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-(cyclopropylmethoxy)-4-(methylsulfonamido)-phenylthio)carbonyloxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 8 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 1034.32 Torr

2: pyridine / 2 h / 0 - 20 °C

3: nitric acid / 1 h / 0 - 20 °C

4: iron; ammonium chloride / ethanol; water / 0.5 h / Reflux

5: hydrogenchloride; sodium nitrite / water / 0.25 h / 5 - 10 °C

6: water / 0.25 h / 65 °C

7: sodium tetrahydroborate; potassium hydroxide / methanol / 2 h / 20 °C

8: dmap / dichloromethane / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; nitric acid; iron; ammonium chloride; potassium hydroxide; sodium nitrite; In pyridine; methanol; ethanol; dichloromethane; water;