4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester

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Chemical Name:4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester
CAS No.:1426421-97-7
Molecular Formula:C₃₄H₃₈FN₇O₆Si
Molecular Weight:687.803
Hs Code.:

4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester

Synonyms:4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester

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Chemical Property of 4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester

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Technology Process of 4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester

There total 8 articles about 4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1426421-95-5
2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [1-(cis-3-hydroxy-cyclobutyl)-ethyl]-amide

: 62-23-7
4-nitro-benzoic acid

: 1426421-97-7
4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 20249-16-5
3-oxo-cyclobutanecarbonitrile

: 1426421-97-7
4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol; sodium tetrahydroborate / 1 h / 0 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane / 2.5 h / -70 - 0 °C

3.2: 1 h / 20 °C

4.1: copper(II) sulfate / dichloromethane / 20 °C

5.1: dichloromethane; diethyl ether / 1 h / 0 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 20 °C

7.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

8.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; methanol; sodium tetrahydroborate; diisobutylaluminium hydride; copper(II) sulfate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 88315-79-1,88315-80-4
(1s,3s)-3-hydroxycyclobutane-1-carbonitrile

: 1426421-97-7
4-nitrobenzoic acid trans-3-(1-{[2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbonyl]-amino}-ethyl)-cyclobutyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 2.5 h / -70 - 0 °C

2.2: 1 h / 20 °C

3.1: copper(II) sulfate / dichloromethane / 20 °C

4.1: dichloromethane; diethyl ether / 1 h / 0 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 20 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

7.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; diisobutylaluminium hydride; copper(II) sulfate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;