[2-(4-methylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene

Base Information

• Chemical Name: [2-(4-methylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene
• CAS No.: 1173280-49-3
• Molecular Formula: C₁₇H₁₂F₆
• Molecular Weight: 330.273
• Mol file: 1173280-49-3.mol

Synonyms:[2-(4-methylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene

Chemical Property of [2-(4-methylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene

Chemical Property:

Purity/Quality:

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Technology Process of [2-(4-methylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene

There total 2 articles about [2-(4-methylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + 3,6-bis(trifluoromethyl)bromobenzene (328-70-1) → [2-(4-methylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene (1173280-49-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutylammonium acetate; tri tert-butylphosphoniumtetrafluoroborate; at 120 ℃; for 30h; Reagent/catalyst; Solvent; Temperature; Sealed tube; Inert atmosphere; Green chemistry;

DOI:10.1039/d1gc02311j

Reference yield: 81.0%

3,5-Bis(trifluoromethyl)benzaldehyde (401-95-6) + 4-methylbenzyltriphenylphosphonium bromide (2378-86-1) → [2-(4-methylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene (1173280-49-3)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo900785k

Reference yield: 59.0%

[2-(4-methylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene (1173280-49-3) → [2-(4-bromomethylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene (1173280-61-9)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 72h; Reflux; Inert atmosphere;

DOI:10.1021/jo900785k

upstream raw materials:

3,5-Bis(trifluoromethyl)benzaldehyde

4-methylbenzyltriphenylphosphonium bromide

1-ethenyl-4-methylbenzene

3,6-bis(trifluoromethyl)bromobenzene

Downstream raw materials:

[2-(4-bromomethylphenyl)-(E)-ethenyl]-3,5-di-(trifluoromethyl)-benzene