(3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine

Base Information

Chemical Name:(3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine
CAS No.:1160501-81-4
Molecular Formula:C₁₇H₁₅F₃N₄O
Molecular Weight:348.328
Hs Code.:

Synonyms:(3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine

Suppliers and Price of (3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of (3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine

There total 10 articles about (3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: C₃₆H₂₉F₃N₄O

: 1160501-81-4
(3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.416667h;
DOI:10.1021/acsmedchemlett.9b00134

Reference yield:

: 1160502-41-9
ethyl 2-(3-(3-bromophenyl)oxetan-3-yl)acetate

: 1160501-81-4
(3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2.1: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 60 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 3.25 h

4.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 1 h / 85 °C

4.2: 0.17 h / 20 °C

5.1: trifluoroacetic acid; triethylsilane / dichloromethane / 0.42 h / 0 - 20 °C

With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; diphenyl phosphoryl azide; water; potassium acetate; sodium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/acsmedchemlett.9b00134

Reference yield:

: C₁₉H₂₇BO₅

: 1160501-81-4
(3-(3-(3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)oxetan-3-yl)methanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 60 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 3.25 h

3.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 1 h / 85 °C

3.2: 0.17 h / 20 °C

4.1: trifluoroacetic acid; triethylsilane / dichloromethane / 0.42 h / 0 - 20 °C

With triethylsilane; bis(tri-t-butylphosphine)palladium⁽⁰⁾; diphenyl phosphoryl azide; water; sodium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/acsmedchemlett.9b00134