2,2,2-trichloro-N-((2E)-4,4-difluoro-1-phenylhexa-2,5-dienyl)acetamide

Base Information

Chemical Name:2,2,2-trichloro-N-((2E)-4,4-difluoro-1-phenylhexa-2,5-dienyl)acetamide
CAS No.:1415354-79-8
Molecular Formula:C₁₄H₁₂Cl₃F₂NO
Molecular Weight:354.611
Hs Code.:

Synonyms:2,2,2-trichloro-N-((2E)-4,4-difluoro-1-phenylhexa-2,5-dienyl)acetamide

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Chemical Property of 2,2,2-trichloro-N-((2E)-4,4-difluoro-1-phenylhexa-2,5-dienyl)acetamide

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Technology Process of 2,2,2-trichloro-N-((2E)-4,4-difluoro-1-phenylhexa-2,5-dienyl)acetamide

There total 2 articles about 2,2,2-trichloro-N-((2E)-4,4-difluoro-1-phenylhexa-2,5-dienyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1415355-02-0
C₁₄H₁₂Cl₃F₂NO

: 88257-89-0
(1E)-4,4-difluoro-1-phenylhexa-1,5-dien-3-ol

: 545-06-2
trichloroacetonitrile

: 1415354-79-8
2,2,2-trichloro-N-((2E)-4,4-difluoro-1-phenylhexa-2,5-dienyl)acetamide

Guidance literature:: (1E)-4,4-difluoro-1-phenylhexa-1,5-dien-3-ol; trichloroacetonitrile; With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 0 ℃; for 0.5h; Inert atmosphere;

C₁₄H₁₂Cl₃F₂NO; With dichloro bis(acetonitrile) palladium(II); In dichloromethane; at 40 ℃; for 4h; regioselective reaction; Reflux;
DOI:10.1016/j.tetlet.2012.10.045 DOI:10.1016/j.tetlet.2012.10.045

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 1415354-79-8
2,2,2-trichloro-N-((2E)-4,4-difluoro-1-phenylhexa-2,5-dienyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: indium / N,N-dimethyl-formamide / 22 h / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 40 °C / Reflux

With indium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; 2.2: |Overman Rearrangement;
DOI:10.1016/j.tetlet.2012.10.045 DOI:10.1016/j.tetlet.2012.10.045