tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate

Base Information

Chemical Name:tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate
CAS No.:1350910-37-0
Molecular Formula:C₄₄H₅₀N₂O₂
Molecular Weight:638.893
Hs Code.:

Synonyms:tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate

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Chemical Property of tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate

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Technology Process of tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate

There total 1 articles about tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1350909-98-6
tert-butyl (RS,E)-4-(N,N-dibenzylamino)-5-phenylpent-2-enoate

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 308273-67-8,680185-65-3
(S)-N-3,4-dimethoxybenzyl-N-(α-methylbenzyl)amine

: 1350910-37-0
tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate

: 1350910-18-7
tert-butyl (3R,4R,αS)-3-[N-3',4'-dimethoxybenzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; (S)-N-3,4-dimethoxybenzyl-N-(α-methylbenzyl)amine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

tert-butyl (RS,E)-4-(N,N-dibenzylamino)-5-phenylpent-2-enoate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/ol203011u

Reference yield:

: 1350910-37-0
tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate

: 1350910-23-4
C₁₅H₂₄N₂O₂

Guidance literature:: With hydrogenchloride; 20 % Pd(OH)2/C; hydrogen; In methanol; at 20 ℃; for 48h; under 3800.26 Torr;
DOI:10.1021/ol203011u

Reference yield:

: 1350910-37-0
tert-butyl (3S,4S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N,N-dibenzylamino)-5-phenylpentanoate

: C₁₁H₁₄N₂O

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; 20 % Pd(OH)2/C; hydrogen / methanol / 48 h / 20 °C / 3800.26 Torr

2: hydrogenchloride / water / 18 h / 90 °C

With hydrogenchloride; 20 % Pd(OH)2/C; hydrogen; In methanol; water;
DOI:10.1021/ol203011u