Technology Process of 4-(2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzenesulfonamide
There total 10 articles about 4-(2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jm401395s
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid; sodium acetate; Iodine monochloride / 3 h / 75 °C
2.1: triethylamine / dichloromethane / 1.7 h / 20 °C / Cooling with ice
3.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
4.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.17 h / 60 °C / Inert atmosphere
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; methanol / 2 h / 40 °C
5.2: 3 h / 20 °C
6.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere
7.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; sodium acetate; Iodine monochloride; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401395s
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 1.7 h / 20 °C / Cooling with ice
2.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
3.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.17 h / 60 °C / Inert atmosphere
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; methanol / 2 h / 40 °C
4.2: 3 h / 20 °C
5.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere
6.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401395s
![tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-(N,N-dimethylsulfamoyl)phenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate](/Databaselist/images/loading.webp)
