C₁₅H₁₄FN₃O₃

Base Information

• Chemical Name: C₁₅H₁₄FN₃O₃
• CAS No.: 1567437-74-4
• Molecular Formula: C₁₅H₁₄FN₃O₃
• Molecular Weight: 303.293
• Mol file: 1567437-74-4.mol

Synonyms:C₁₅H₁₄FN₃O₃

Chemical Property of C₁₅H₁₄FN₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₁₅H₁₄FN₃O₃

There total 2 articles about C₁₅H₁₄FN₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-iodonitrobenzene (645-00-1) + C9H11FN2O (1567437-80-2) → C15H14FN3O3 (1567437-74-4)

Guidance literature:

With copper(l) iodide; 3,4,7,8-Tetramethyl-o-phenanthrolin; caesium carbonate; In tetrahydrofuran; at 100 ℃; for 18h;

DOI:10.1016/j.bmcl.2014.01.001

Reference yield:

2,4-difluoropyridine (34941-90-7) → C15H14FN3O3 (1567437-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 60 °C

2: caesium carbonate; copper(l) iodide; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 18 h / 100 °C

With copper(l) iodide; 3,4,7,8-Tetramethyl-o-phenanthrolin; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.01.001

Reference yield:

C15H14FN3O3 (1567437-74-4) → C15H16FN3O (1567436-74-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 2h; under 2068.65 Torr;

DOI:10.1016/j.bmcl.2014.01.001

upstream raw materials:

m-iodonitrobenzene

C₉H₁₁FN₂O

2,4-difluoropyridine

Downstream raw materials:

C₁₅H₁₆FN₃O