2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid

Base Information

Chemical Name:2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid
CAS No.:136630-85-8
Molecular Formula:C₁₇H₂₃NO₇S
Molecular Weight:385.438
Hs Code.:

Synonyms:2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid

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Chemical Property of 2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid

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Technology Process of 2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid

There total 5 articles about 2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 114343-86-1
2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>thio>acetic acid

: 136630-84-7
2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfinyl>acetic acid

: 136630-85-8
2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid

Guidance literature:: With magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1021/jm00115a016

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 136630-85-8
2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine (NMM) / ethyl acetate / 0.17 h / -10 °C

2: diethyl ether / 3 h / Ambient temperature

3: 47percent aq. HBr / dioxane / 1 h / 0 °C

4: 1.) NaOMe / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 1 h

5: 47 percent / magnesium monoperoxyphthalate / tetrahydrofuran / 1 h / Ambient temperature

With 4-methyl-morpholine; hydrogen bromide; sodium methylate; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethyl acetate;
DOI:10.1021/jm00115a016

Reference yield:

: 68709-71-7
tert-butyl 4-bromo-3-oxo-1-phenylbutan-2-ylcarbamate

: 136630-85-8
2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaOMe / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 1 h

2: 47 percent / magnesium monoperoxyphthalate / tetrahydrofuran / 1 h / Ambient temperature

With sodium methylate; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran;
DOI:10.1021/jm00115a016