tert-butyl (1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate

Base Information

• Chemical Name: tert-butyl (1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate
• CAS No.: 526217-57-2
• Molecular Formula: C₁₅H₂₃NO₄
• Molecular Weight: 281.352
• Mol file: 526217-57-2.mol

Synonyms:tert-butyl (1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate

Chemical Property of tert-butyl (1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate

There total 4 articles about tert-butyl (1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-(3-methoxyphenyl)ethyl benzoate → tert-butyl (1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate (526217-57-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 20h;

DOI:10.1016/S0968-0896(02)00380-2

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate (526217-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 M NaOH / dioxane / 3 h / 0 °C

2: 96 percent / PPh₃; DEAD / tetrahydrofuran; toluene / 2 h / 0 °C

3: 51 percent / 1 M NaOH / tetrahydrofuran; methanol / 20 h / 20 °C

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; 2: Mitsunobu reaction;

DOI:10.1016/S0968-0896(02)00380-2

Reference yield:

tert-butyl (1S,2R)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate (526217-27-6) → tert-butyl (1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate (526217-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / PPh₃; DEAD / tetrahydrofuran; toluene / 2 h / 0 °C

2: 51 percent / 1 M NaOH / tetrahydrofuran; methanol / 20 h / 20 °C

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene; 1: Mitsunobu reaction;

DOI:10.1016/S0968-0896(02)00380-2

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl (1S,2R)-2-hydroxy-1-(3-methoxyphenyl)propylcarbamate

Downstream raw materials:

N-[(1S,2S)-2-hydroxy-1-(3-methoxyphenyl)propyl]octanamide