6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Base Information

• Chemical Name: 6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol
• CAS No.: 862130-05-0
• Molecular Formula: C₃₀H₃₇NO₅S
• Molecular Weight: 523.693
• Mol file: 862130-05-0.mol

Synonyms:6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Chemical Property of 6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

There total 13 articles about 6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-6-(4-methanesulfonyl-cyclohex-1-enyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol (862129-77-9) → 6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol (862130-05-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2007.04.044

Reference yield:

6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalene-2-ol (648904-49-8) → 6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol (862130-05-0)

Guidance literature:

Multi-step reaction with 4 steps

1: PCy₃; CsF / Pd(OAc)2

2: BBr₃; isobutene / CH₂Cl₂

3: H₂ / Pd/C / tetrahydrofuran; ethanol

With hydrogen; boron tribromide; cesium fluoride; isobutene; tricyclohexylphosphine; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2007.04.044

Reference yield:

2-(benzyloxy)-1-bromo-6-methoxynaphthalene (648904-47-6) → 6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol (862130-05-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 30 percent / copper triflate

2: NH₄HCO₂ / Pd(OH)2

3: PCy₃; CsF / Pd(OAc)2

4: BBr₃; isobutene / CH₂Cl₂

5: H₂ / Pd/C / tetrahydrofuran; ethanol

With hydrogen; ammonium formate; boron tribromide; copper(I) triflate; cesium fluoride; isobutene; tricyclohexylphosphine; palladium diacetate; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 1: Ullman coupling / 4: Suzuki coupling;

DOI:10.1016/j.bmcl.2007.04.044

upstream raw materials:

(+/-)-6-(4-methanesulfonyl-cyclohex-1-enyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

2-(benzyloxy)-1-bromo-6-methoxynaphthalene

6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalene-2-ol

1-{2-[4-(2-benzyloxy-6-methoxynaphthalen-1-yloxy)phenoxy]ethyl}piperidine