(R)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol

Base Information

• Chemical Name: (R)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol
• CAS No.: 900159-62-8
• Molecular Formula: C₄₁H₇₂O₄S₂Si
• Molecular Weight: 721.238
• Mol file: 900159-62-8.mol

Synonyms:(R)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol

Chemical Property of (R)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol

There total 38 articles about (R)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanone (900159-63-9) → (R)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol (900159-62-8) + (S)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol

Guidance literature:

With lithium borohydride; In tetrahydrofuran; methanol; at 0 - 25 ℃;

DOI:10.1021/jo0605086

Reference yield: 68.0%

2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanone (900159-63-9) → (R)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol (900159-62-8)

Guidance literature:

With dimethylsulfide borane complex; (S)-CBS-catalyst; In tetrahydrofuran; at 15 ℃; for 12h;

DOI:10.1021/jo0605086

Reference yield: 51.0%

[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-acetaldehyde (900152-57-0) + tert-butyl-[3-(2-[1,3]dithian-2-yl-propyl)-1-propyl-but-3-enyloxy]-dimethyl-silane (900152-58-1) → (R)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol (900159-62-8) + (S)-2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanol

Guidance literature:

tert-butyl-[3-(2-[1,3]dithian-2-yl-propyl)-1-propyl-but-3-enyloxy]-dimethyl-silane; With tert.-butyl lithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; pentane; at -78 ℃;

[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-acetaldehyde; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; pentane; at -78 ℃; for 1h;

DOI:10.1021/jo0605086

upstream raw materials:

[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-acetaldehyde

tert-butyl-[3-(2-[1,3]dithian-2-yl-propyl)-1-propyl-but-3-enyloxy]-dimethyl-silane

2-[(2R,4S,5S)-5-((S)-6-Benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethanone

(2R)-4-((2R)-2-[1-(tert-butyl)-1,1-dimethylsilyl]oxypentyl)-2-methyl-4-pentenal

Downstream raw materials:

Acetic acid (R)-2-[(2R,4S,5S)-5-((S)-6-benzyloxy-5-methyl-hexyl)-4-methyl-tetrahydro-furan-2-yl]-1-{2-[(1R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-1-methyl-3-methylene-octyl]-[1,3]dithian-2-yl}-ethyl ester