Technology Process of 18-hydroxy-4-androstene-3,17-dione
There total 8 articles about 18-hydroxy-4-androstene-3,17-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2.1 g / p-toluenesulfonic acid monohydrate, 30percent aq. H2O2 / dioxane / 1 h / 10 °C
2: 2.52 g / pyridine / 17 h / 8 - 20 °C
3: 0.62 g / 25percent aq. Me3N / dioxane / 1.5 h / Heating
4: 1.) pyridinium dichromate, 2.) K2CO3 / 1.) CH2Cl2, RT, 17 h, 2.) water, methanol, sonication, RT, 10 min
With
pyridine; dipyridinium dichromate; dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; trimethylamine;
In
1,4-dioxane;
DOI:10.1016/0039-128X(93)90051-N
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2.52 g / pyridine / 17 h / 8 - 20 °C
2: 0.62 g / 25percent aq. Me3N / dioxane / 1.5 h / Heating
3: 1.) pyridinium dichromate, 2.) K2CO3 / 1.) CH2Cl2, RT, 17 h, 2.) water, methanol, sonication, RT, 10 min
With
pyridine; dipyridinium dichromate; potassium carbonate; trimethylamine;
In
1,4-dioxane;
DOI:10.1016/0039-128X(93)90051-N
