3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoic acid sodium salt

Base Information

Chemical Name:3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoic acid sodium salt
CAS No.:1354902-13-8
Molecular Formula:C₃₁H₂₀FN₄O₅*Na
Molecular Weight:570.512
Hs Code.:

Synonyms:3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoic acid sodium salt

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Chemical Property of 3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoic acid sodium salt

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Technology Process of 3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoic acid sodium salt

There total 11 articles about 3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 274-47-5
imidazo[1,5-a]pyridine

: 1354902-13-8
3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoic acid sodium salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 1,2-dichloro-ethane / 4.5 h / 0 - 20 °C / Inert atmosphere

1.2: 20 - 80 °C / Inert atmosphere

2.1: N-Bromosuccinimide / dichloromethane / 2.5 h / Inert atmosphere

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / 90 °C / Inert atmosphere

3.3: 24 h / 20 °C

4.1: 1,4-dioxane / 7 h / 20 °C / Inert atmosphere; Reflux

4.2: 3 h / 20 °C / Reflux

5.1: sodium hydroxide; water / methanol / 2 h / Reflux

6.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

7.1: water; lithium hydroxide / tetrahydrofuran / 5 h / Reflux

7.2: 5 °C

With N-Bromosuccinimide; water; potassium carbonate; caesium carbonate; triethylamine; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;

Reference yield:

: 1354902-42-3
methyl 3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoate

: 1354902-13-8
3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoic acid sodium salt

Guidance literature:: methyl 3-(3-{[3-(4-fluorobenzyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]carbonyl}imidazo[1,5-a]pyridin-1-yl)benzoate; With water; lithium hydroxide; In tetrahydrofuran; for 5h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 5 ℃;

With sodium hydroxide; In methanol; water;