5-(2,4-bis(trifluoromethyl)phenyl)-1,1-dioxo-2-quinolin-4-ylmethyl-1,2-dihydro-1-benzo[d]isothiazol-3-one

Base Information

Chemical Name:5-(2,4-bis(trifluoromethyl)phenyl)-1,1-dioxo-2-quinolin-4-ylmethyl-1,2-dihydro-1-benzo[d]isothiazol-3-one
CAS No.:1202040-46-7
Molecular Formula:C₂₅H₁₄F₆N₂O₃S
Molecular Weight:536.454
Hs Code.:

Synonyms:5-(2,4-bis(trifluoromethyl)phenyl)-1,1-dioxo-2-quinolin-4-ylmethyl-1,2-dihydro-1-benzo[d]isothiazol-3-one

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Chemical Property of 5-(2,4-bis(trifluoromethyl)phenyl)-1,1-dioxo-2-quinolin-4-ylmethyl-1,2-dihydro-1-benzo[d]isothiazol-3-one

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Technology Process of 5-(2,4-bis(trifluoromethyl)phenyl)-1,1-dioxo-2-quinolin-4-ylmethyl-1,2-dihydro-1-benzo[d]isothiazol-3-one

There total 4 articles about 5-(2,4-bis(trifluoromethyl)phenyl)-1,1-dioxo-2-quinolin-4-ylmethyl-1,2-dihydro-1-benzo[d]isothiazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 153254-09-2
2,4-bis(trifluoromethyl)phenylboronic acid

: 1202040-91-2
5-bromo-2-(quinolin-4-ylmethyl)aminosulfonyl-benzoic acid methyl ester

: 1202040-46-7
5-(2,4-bis(trifluoromethyl)phenyl)-1,1-dioxo-2-quinolin-4-ylmethyl-1,2-dihydro-1-benzo[d]isothiazol-3-one

Guidance literature:: With PS-DIPEA; bis-triphenylphosphine-palladium(II) chloride; tri tert-butylphosphoniumtetrafluoroborate; In water; acetonitrile; for 8h; Reflux;

Reference yield:

: 5632-13-3
1-quinolin-4-ylmethanamine

: 1202040-46-7
5-(2,4-bis(trifluoromethyl)phenyl)-1,1-dioxo-2-quinolin-4-ylmethyl-1,2-dihydro-1-benzo[d]isothiazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 10 h / 20 °C

2: PS-DIPEA / bis-triphenylphosphine-palladium(II) chloride; tri tert-butylphosphoniumtetrafluoroborate / water; acetonitrile / 8 h / Reflux

With PS-DIPEA; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tri tert-butylphosphoniumtetrafluoroborate; In dichloromethane; water; acetonitrile;

Reference yield:

: 52727-57-8
5-bromo-2-aminobenzoic acid methyl ester

: 1202040-46-7
5-(2,4-bis(trifluoromethyl)phenyl)-1,1-dioxo-2-quinolin-4-ylmethyl-1,2-dihydro-1-benzo[d]isothiazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 °C

1.2: 0 - 50 °C

2.1: triethylamine / dichloromethane / 10 h / 20 °C

3.1: PS-DIPEA / bis-triphenylphosphine-palladium(II) chloride; tri tert-butylphosphoniumtetrafluoroborate / water; acetonitrile / 8 h / Reflux

With hydrogenchloride; PS-DIPEA; triethylamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; tri tert-butylphosphoniumtetrafluoroborate; In dichloromethane; water; acetonitrile;