7-methoxy-5-((4-methylbenzyloxy)methyl)-3-(phenyl(3-(trifluoromethyl)phenyl)methyl)benzofuran

Base Information

• Chemical Name: 7-methoxy-5-((4-methylbenzyloxy)methyl)-3-(phenyl(3-(trifluoromethyl)phenyl)methyl)benzofuran
• CAS No.: 1338381-16-0
• Molecular Formula: C₃₂H₂₇F₃O₃
• Molecular Weight: 516.56

Synonyms:7-methoxy-5-((4-methylbenzyloxy)methyl)-3-(phenyl(3-(trifluoromethyl)phenyl)methyl)benzofuran

Chemical Property of 7-methoxy-5-((4-methylbenzyloxy)methyl)-3-(phenyl(3-(trifluoromethyl)phenyl)methyl)benzofuran

Chemical Property:

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Technology Process of 7-methoxy-5-((4-methylbenzyloxy)methyl)-3-(phenyl(3-(trifluoromethyl)phenyl)methyl)benzofuran

There total 4 articles about 7-methoxy-5-((4-methylbenzyloxy)methyl)-3-(phenyl(3-(trifluoromethyl)phenyl)methyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1-iodo-3-methoxy-5-((4-methylbenzyloxy)methyl)-2-(3-phenyl-3-(3-(trifluoromethyl)phenyl)allyloxy)benzene → 7-methoxy-5-((4-methylbenzyloxy)methyl)-3-(phenyl(3-(trifluoromethyl)phenyl)methyl)benzofuran (1338381-16-0)

Guidance literature:

With 1,10-Phenanthroline; potassium tert-butylate; In 1,3,5-trimethyl-benzene; at 160 ℃; for 2h;

DOI:10.1039/c1cc14297f

Reference yield:

C16H12BrF3 (136059-35-3) → 7-methoxy-5-((4-methylbenzyloxy)methyl)-3-(phenyl(3-(trifluoromethyl)phenyl)methyl)benzofuran (1338381-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: 1,10-Phenanthroline; potassium tert-butylate / 1,3,5-trimethyl-benzene / 2 h / 160 °C

With 1,10-Phenanthroline; potassium tert-butylate; potassium carbonate; In N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene; 2: Heck reaction;

DOI:10.1039/c1cc14297f

Reference yield:

C16H13F3O → 7-methoxy-5-((4-methylbenzyloxy)methyl)-3-(phenyl(3-(trifluoromethyl)phenyl)methyl)benzofuran (1338381-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; triphenylphosphine / dichloromethane / 0.25 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: 1,10-Phenanthroline; potassium tert-butylate / 1,3,5-trimethyl-benzene / 2 h / 160 °C

With 1,10-Phenanthroline; potassium tert-butylate; bromine; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene; 3: Heck reaction;

DOI:10.1039/c1cc14297f

upstream raw materials:

C₁₆H₁₂BrF₃

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