Pholcodine

Base Information Edit

Chemical Name:Pholcodine
CAS No.:509-67-1
Molecular Formula:C23H30 N2 O4
Molecular Weight:398.502
Hs Code.:
European Community (EC) Number:208-102-9
UNII:LPP64AWZ7L
DSSTox Substance ID:DTXSID70198923
Nikkaji Number:J6.252I
Wikipedia:Pholcodine
Wikidata:Q3124290
NCI Thesaurus Code:C87365
Metabolomics Workbench ID:49672
ChEMBL ID:CHEMBL2105224
Mol file:509-67-1.mol

Synonyms:7,8-didehydro-4,5 alpha-epoxy-17-methyl-3-(2-morpholinoethoxymorphinan-6 alpha-ol);homocodeine;pholcodine

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Pholcodine Edit

Chemical Property:

Vapor Pressure:3.44E-14mmHg at 25°C
Melting Point:91°C
Refractive Index:1.6300 (estimate)
Boiling Point:577.8°Cat760mmHg
PKA:pKa 5.30(50% aq EtOH) (Uncertain)
Flash Point:303.2°C
PSA：54.40000
Density:1.34g/cm³
LogP:1.07930
Solubility.:Sparingly soluble in water, freely soluble in acetone and in ethanol (96 per cent). It dissolves in dilute mineral acids.
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:398.22055744
Heavy Atom Count:29
Complexity:653

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC23C4C1CC5=C2C(=C(C=C5)OCCN6CCOCC6)OC3C(C=C4)O
Isomeric SMILES:CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OCCN6CCOCC6)O[C@H]3[C@H](C=C4)O
Recent EU Clinical Trials:A multicenter, randomized, parallel group, controlled, double-blind study to evaluate efficacy and safety of pholcodine as antitussive agent vs dextrometorphan in non-productive cough
Uses antimalarial derivative of natural artemisinin Antitussive; an opioid cough suppressant. Controlled Substance.

Technology Process of Pholcodine

There total 2 articles about Pholcodine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 110-91-8,99108-56-2
morpholine

: C₁₉H₂₂BrNO₃

: 509-67-1
pholcodine

Guidance literature:: With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 7h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;