1-(3,4-Dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

Base Information

Chemical Name:1-(3,4-Dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide
CAS No.:16659-88-4
Molecular Formula:C16H17 N O4 . Br H
Molecular Weight:368.22
Hs Code.:2933499090
European Community (EC) Number:630-581-1
NSC Number:118071
UNII:D7HN447UC9
Mol file:16659-88-4.mol

Synonyms:16659-88-4;(+/-)-Tetrahydropapaveroline hydrobromide;1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide;Tetrahydropapaveroline hydrobromide;THPV HBr;NSC-118071;1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol;hydrobromide;D7HN447UC9;Norlaudanosoline hydrobromide;6,7-Isoquinolinediol, 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-, hydrobromide (1:1);Bromhydrate de tetrahydropapaveroline;6,7-ISOQUINOLINEDIOL, 1-((3,4-DIHYDROXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO-, HYDROBROMIDE (1:1);ST056944;1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol Hydrobromide;C16H17NO4.BrH;SCHEMBL3276906;1,3,4-Tetrahydropapaveroline HBr;C16-H17-N-O4.Br-H;NSC118071;AKOS022181284;1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol, bromi de;EN300-27660;Papaveroline,2,3,4-tetrahydro-, hydrobromide;(+/-)-TETRAHYDROPAPAVEROLINEHYDROBROMIDE;6,7-Isoquinolinediol, 1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-, HBr (9CI)

Suppliers and Price of 1-(3,4-Dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NorlaudanosolineHydrobromide
250mg
$ 1695.00

Medical Isotopes, Inc.
NorlaudanosolineHBr
250 mg
$ 2400.00

Chemenu
1-(3,4-Dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diolhydrobromide 95%
250mg
$ 1964.00

American Custom Chemicals Corporation
(+/-)-TETRAHYDRO PAPAVEROLINE HYDROBROMIDE 95.00%
5MG
$ 495.90

Total 19 raw suppliers

Chemical Property of 1-(3,4-Dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

Chemical Property:

Vapor Pressure:9.67E-14mmHg at 25°C
Melting Point:277 °C (dec.)(lit.)
Boiling Point:573.2°Cat760mmHg
Flash Point:235.1°C
PSA：92.95000
Density:1.406g/cm³
LogP:3.22540
Storage Temp.:Amber Vial, Refrigerator
Solubility.:DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:367.04192
Heavy Atom Count:22
Complexity:353

Purity/Quality:

99% ^*data from raw suppliers

NorlaudanosolineHydrobromide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22
Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC(=C(C=C3)O)O.Br
Uses Norlaudanosoline is a key intermediate on the biosynthetic pathway to morphinan and benzylisoquinoline alkaloids.

Technology Process of 1-(3,4-Dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

There total 7 articles about 1-(3,4-Dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

: 6429-04-5,66820-84-6
1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

: 16659-88-4
(+/-)-Tetrahydropapaveroline hydrobromide

Guidance literature:: With hydrogen bromide; for 2.5h; Reflux;
DOI:10.3987/COM-10-11912

Reference yield: 95.0%

: 13168-51-9
N-benzoyl-norreticuline

: 16659-88-4
(+/-)-Tetrahydropapaveroline hydrobromide

Guidance literature:: With hydrogen bromide; for 2h; Heating;
DOI:10.1021/jo01292a008

Reference yield:

: 1131-94-8
homoisovanillic acid

: 16659-88-4
(+/-)-Tetrahydropapaveroline hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: 90.4 percent / Heating

2: POCl₃ / acetonitrile / Heating

3: NaBH₄

4: 95 percent / aqueous HBr / 2 h / Heating

With sodium tetrahydroborate; hydrogen bromide; trichlorophosphate; In acetonitrile;
DOI:10.1021/jo01292a008