(S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-5-ethyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:(S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-5-ethyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine
CAS No.:1310692-63-7
Molecular Formula:C₂₈H₂₉N₇
Molecular Weight:463.585
Hs Code.:

Synonyms:(S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-5-ethyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine

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Chemical Property of (S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-5-ethyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine

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Technology Process of (S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-5-ethyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine

There total 8 articles about (S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-5-ethyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1310693-02-7
(S)-5-ethyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

: 1310692-63-7
(S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-5-ethyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: With hydrogenchloride; In acetone; at 25 ℃; for 3h;
DOI:10.1021/jm200409s

Reference yield:

: 1310692-68-2
2-amino-6-ethyl-4-methylnicotinamide

: 1310692-63-7
(S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-5-ethyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: [bis(acetoxy)iodo]benzene; potassium hydroxide / methanol / 0 - 25 °C

2: isobutyric Acid; magnesium chloride / 24 h / 25 - 120 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

4: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere

5: hydrogenchloride / acetone / 3 h / 25 °C

With hydrogenchloride; [bis(acetoxy)iodo]benzene; palladium diacetate; potassium carbonate; triphenylphosphine; isobutyric Acid; potassium hydroxide; magnesium chloride; diethylazodicarboxylate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetone; 1: Hofmann rearrangement / 3: Mitsunobu reaction / 4: Suzuki coupling;
DOI:10.1021/jm200409s

Reference yield:

: 1310692-72-8
5-ethyl-7-methyl-1H-imidazo[4,5-b]pyridin-2-(3H)-one

: 1310692-63-7
(S)-3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-5-ethyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: isobutyric Acid; magnesium chloride / 24 h / 25 - 120 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

3: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere

4: hydrogenchloride / acetone / 3 h / 25 °C

With hydrogenchloride; palladium diacetate; potassium carbonate; triphenylphosphine; isobutyric Acid; magnesium chloride; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; water; acetone; 2: Mitsunobu reaction / 3: Suzuki coupling;
DOI:10.1021/jm200409s