2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester

Base Information

Chemical Name:2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester
CAS No.:1026522-51-9
Molecular Formula:C₃₇H₂₉BrO₃S
Molecular Weight:633.605
Hs Code.:

2-[4'-(2-benzyl-benzo[<i>b</i>]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester

Synonyms:2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester

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Chemical Property of 2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester

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Technology Process of 2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester

There total 9 articles about 2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13673-95-5
(S)-methyl 2-hydroxy-3-phenylpropanoate

: 250279-18-6
4'-(2-benzyl-benzo[b]thiophene-3-yl)-3-bromo-biphenyl-4-ol

: 1026522-51-9
2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In benzene; at 20 ℃; for 0.5h;
DOI:10.1021/jm990560c

Reference yield:

: 7342-82-7
3-Bromothianaphthene

: 1026522-51-9
2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / Pd(OAc)2; aq. K₂CO₃ / acetone / 2 h / 65 °C

2.1: BBr₃ / CH₂Cl₂ / 10 h / 20 °C

3.1: n-BuLi / tetrahydrofuran / 3 h / -40 °C

3.2: tetrahydrofuran / 0.5 h / 0 °C

4.1: hydrazine monohydrate; diethylene glycol / 1 h / 180 °C

4.2: KOH / 10 h / 130 °C

5.1: Br₂; KOAc / acetic acid / 0.17 h / 5 °C

6.1: diethylazodicarboxylate; PPh₃ / benzene / 0.5 h / 20 °C

With palladium diacetate; n-butyllithium; bromine; potassium acetate; boron tribromide; potassium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; diethylene glycol; In tetrahydrofuran; dichloromethane; acetic acid; acetone; benzene; 1.1: Cyclization / 2.1: demethylation / 3.1: Metallation / 3.2: Acylation / 4.1: Wolff-Kishner reduction / 4.2: Wolff-Kishner reduction / 5.1: Bromination / 6.1: Alkylation;
DOI:10.1021/jm990560c

Reference yield:

: 100-68-5
methyl-phenyl-thioether

: 1026522-51-9
2-[4'-(2-benzyl-benzo[b]thiophen-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi; tetramethylenediamine / diethyl ether / 12 h / 20 °C

1.2: 23 percent / diethyl ether / 20 h / 20 °C

2.1: BBr₃ / CH₂Cl₂ / 10 h / 20 °C

3.1: n-BuLi / tetrahydrofuran / 3 h / -40 °C

3.2: tetrahydrofuran / 0.5 h / 0 °C

4.1: hydrazine monohydrate; diethylene glycol / 1 h / 180 °C

4.2: KOH / 10 h / 130 °C

5.1: Br₂; KOAc / acetic acid / 0.17 h / 5 °C

6.1: diethylazodicarboxylate; PPh₃ / benzene / 0.5 h / 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; bromine; potassium acetate; boron tribromide; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; diethylene glycol; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; benzene; 1.1: Metallation / 1.2: Cyclization / 2.1: demethylation / 3.1: Metallation / 3.2: Acylation / 4.1: Wolff-Kishner reduction / 4.2: Wolff-Kishner reduction / 5.1: Bromination / 6.1: Alkylation;
DOI:10.1021/jm990560c