(1S,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol

Base Information

• Chemical Name: (1S,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol
• CAS No.: 33651-16-0
• Molecular Formula: C₁₈H₂₄O
• Molecular Weight: 256.388
• Mol file: 33651-16-0.mol

Synonyms:(1S,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol

Chemical Property of (1S,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol

There total 6 articles about (1S,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) + phenylacetylene (536-74-3) → (1S,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol (33651-16-0) + (1R,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol (33651-17-1)

Guidance literature:

phenylacetylene; With n-butyllithium; cerium(III) chloride; In tetrahydrofuran; at -78 ℃; for 1h;

(2R,5S)-menthone; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1021/jo000810t

Reference yield:

(2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) + lithium phenylacetylide (4440-01-1) → (1S,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol (33651-16-0)

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1021/ja982525l

Reference yield:

2,2-dibromostyrene (7436-90-0) + (2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) → (1S,2S,5R)-2-isopropyl-5-methyl-1-{2-phenyl-1-ethyn-1-yl}cyclohexan-1-ol (33651-16-0)

Guidance literature:

With n-butyllithium; cerium(III) chloride; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(99)00055-6

upstream raw materials:

(2R,5S)-menthone

phenylacetylene

2,2-dibromostyrene

lithium phenylacetylide

Downstream raw materials:

C₃₀H₃₃OP

(R)-3,3-Dimethyl-2-phenyl-1-butanol

{(R)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-benzene

Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-styryl)-cyclohexyl ester methyl ester