1-(2-Bromo-cyclohex-1-enylmethyl)-cyclohex-2-enecarboxylic acid ethyl ester

Base Information

Chemical Name:1-(2-Bromo-cyclohex-1-enylmethyl)-cyclohex-2-enecarboxylic acid ethyl ester
CAS No.:134079-20-2
Molecular Formula:C₁₆H₂₃BrO₂
Molecular Weight:327.261
Hs Code.:

Synonyms:1-(2-Bromo-cyclohex-1-enylmethyl)-cyclohex-2-enecarboxylic acid ethyl ester

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Chemical Property of 1-(2-Bromo-cyclohex-1-enylmethyl)-cyclohex-2-enecarboxylic acid ethyl ester

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Technology Process of 1-(2-Bromo-cyclohex-1-enylmethyl)-cyclohex-2-enecarboxylic acid ethyl ester

There total 4 articles about 1-(2-Bromo-cyclohex-1-enylmethyl)-cyclohex-2-enecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134109-81-2
6-<(2-Bromocyclohexyl)methyl>-6-(ethoxycarbonyl)-cyclohex-1-en-1-yl triflate

: 134109-83-4
1,2,3,4,6,7,8,9-Octahydro-fluorene-8a-carboxylic acid ethyl ester

: 134079-20-2
1-(2-Bromo-cyclohex-1-enylmethyl)-cyclohex-2-enecarboxylic acid ethyl ester

Guidance literature:: With 4 A molecular sieve; tetrabutylammomium bromide; lithium carbonate; trimethylsilyltributyltin; bis-triphenylphosphine-palladium(II) chloride; In toluene; at 110 ℃; for 8h;
DOI:10.1021/jo00011a009

Reference yield:

: 121898-42-8
(2-Bromocyclohex-1-enyl)methyl bromide

: 134079-20-2
1-(2-Bromo-cyclohex-1-enylmethyl)-cyclohex-2-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaH / 1) THF, 30 min, r.t. 2) THF, 17 h, reflux

2: 73 percent / 2,6-di-t-butylpyridine / CH₂Cl₂ / 51 h / 80 °C

3: 13 percent Spectr_. / Bu₄NBr, Li₂CO₃, Bu₃SnSiMe₃, 4A molecular sieves / PdCl₂(PPh₃)2 / toluene / 8 h / 110 °C

With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; tetrabutylammomium bromide; lithium carbonate; sodium hydride; trimethylsilyltributyltin; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; toluene;
DOI:10.1021/jo00011a009

Reference yield:

: 134079-04-2
Ethyl 1-<(2'-bromocyclohexenyl)methyl>-2-oxocyclohexane-1-carboxylate

: 134079-20-2
1-(2-Bromo-cyclohex-1-enylmethyl)-cyclohex-2-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / 2,6-di-t-butylpyridine / CH₂Cl₂ / 51 h / 80 °C

2: 13 percent Spectr_. / Bu₄NBr, Li₂CO₃, Bu₃SnSiMe₃, 4A molecular sieves / PdCl₂(PPh₃)2 / toluene / 8 h / 110 °C

With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; tetrabutylammomium bromide; lithium carbonate; trimethylsilyltributyltin; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; toluene;
DOI:10.1021/jo00011a009